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VPS11 抗体

This anti-VPS11 antibody (ABIN7120703) is a Rabbit Polyclonal antibody detecting VPS11 in WB, ELISA, IP, IF, FACS. Suitable for Human, Mouse, Rat.
产品编号 ABIN7120703
发货至: 中国

Quick Overview for VPS11 抗体 (ABIN7120703)

抗原

See all VPS11 抗体
VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This VPS11 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    vacuolar protein sorting 11 homolog(S. cerevisiae)

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:5000, IF: 1:10-1:100, IP: 1:200-1:2000, FC:N/A

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

    别名

    VPS11

    背景

    Synonyms:END1, hVPS11, PEP5, RING finger protein 108, RNF108, VPS11 Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes(PubMed:21148287). Involved in the retrograde Shiga toxin transport(PubMed:23593995).

    分子量

    108 kDa

    基因ID

    55823

    UniProt

    Q9H270

    途径

    SARS-CoV-2 Protein Interactome
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