ULBP1 抗体
Quick Overview for ULBP1 抗体 (ABIN7120610)
抗原
See all ULBP1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ULBP1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- UL16 binding protein 1
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亚型
- IgG
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anti-UL16 Binding Protein 1 (ULBP1) (AA 26-216) antibody
ULBP1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3A6F11 unconjugated
anti-UL16 Binding Protein 1 (ULBP1) (AA 26-216) antibodyULBP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-UL16 Binding Protein 1 (ULBP1) (AA 26-216) antibodyULBP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-UL16 Binding Protein 1 (ULBP1) (AA 1-244) antibodyULBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-UL16 Binding Protein 1 (ULBP1) (AA 1-234) antibodyULBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-UL16 Binding Protein 1 (ULBP1) (N-Term) antibodyULBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ULBP1 (UL16 Binding Protein 1 (ULBP1))
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别名
- ULBP1
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背景
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Synonyms: UL16-binding protein 1|ALCAN-beta|NKG2D ligand 1 (N2DL-1, NKG2DL1)|Retinoic acid early transcript 1I|ULBP1|N2DL1|RAET1I
Background: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
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分子量
- 30 kDa, 37 kDa
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基因ID
- 80329
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UniProt
- Q9BZM6
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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