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ube3a 抗体

This 兔 多克隆 antibody specifically detects ube3a in WB, IHC 和 ELISA. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN7120486
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for ube3a 抗体 (ABIN7120486)

抗原

See all ube3a 抗体
ube3a (Ubiquitin Protein Ligase E3A (ube3a))

适用

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人, 小鼠, 大鼠

宿主

  • 49
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克隆类型

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  • 11
多克隆

标记

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This ube3a antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 原理

    UBE3A antibody

    纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    ubiquitin protein ligase E3A

    亚型

    IgG
  • 应用备注

    WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    ube3a (Ubiquitin Protein Ligase E3A (ube3a))

    别名

    UBE3A

    背景

    Synonyms: Ubiquitin-protein ligase E3A|E6AP ubiquitin-protein ligase|HECT-type ubiquitin transferase E3A|Human papillomavirus E6-associated protein|Oncogenic protein-associated protein E6-AP|Renal carcinoma antigen NY-REN-54|UBE3A|E6AP|EPVE6AP|HPVE6A

    Background: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

    分子量

    110 kDa

    基因ID

    7337

    UniProt

    Q05086

    途径

    Intracellular Steroid Hormone Receptor Signaling Pathway
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