UBD 抗体
Quick Overview for UBD 抗体 (ABIN7120480)
抗原
See all UBD 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- UBD antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- ubiquitin D
-
亚型
- IgG
-
-
anti-Ubiquitin D (UBD) (AA 1-155) antibody
UBD 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) antibodyUBD 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin D (UBD) (AA 120-153) antibodyUBD 适用: 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (Internal Region) antibodyUBD 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) antibodyUBD 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7D8 unconjugated
-
-
应用备注
- WB: 1:500-1:5000, IHC: 1:20-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- UBD (Ubiquitin D (UBD))
-
别名
- UBD
-
背景
-
Synonyms: Ubiquitin D|Diubiquitin|Ubiquitin-like protein FAT10|UBD|FAT10
Background: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9(PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells(RTECs). May be involved in dendritic cell(DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus(HIV)-associated nephropathy(HIVAN).
-
分子量
- 18 kDa
-
基因ID
- 10537
-
UniProt
- O15205
-
途径
- Ubiquitin Proteasome Pathway
抗原
-
