Tubulin 抗体 (acLys40)
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Quick Overview for Tubulin 抗体 (acLys40) (ABIN7120355)
抗原
See all Tubulin (TUB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- acLys40
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原理
- Acetylated tubulin antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: A synthetic peptide(1-50aa)
Immunogen: tubulin, alpha 1a
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亚型
- IgG1
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应用备注
- WB: 1:500-1:5000, IF: 1:20-1:200, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Tubulin (TUB)
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别名
- tubulin
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背景
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Synonyms: Tubulin alpha-1A chain|Alpha-tubulin 3|Tubulin B-alpha-1|Tubulin alpha-3 chain|Detyrosinated tubulin alpha-1A chain|TUBA1A|TUBA3
Background: Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin, it does not recognize non-acetylated tubulin.
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分子量
- 52 kDa
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基因ID
- 7846
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UniProt
- Q71U36
抗原
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