SOCS1 抗体
Quick Overview for SOCS1 抗体 (ABIN7119604)
抗原
See all SOCS1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SOCS1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: peptide
Immunogen: Suppressor of cytokine signaling 1
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50-1:200, IF: 1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
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别名
- SOCS1
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背景
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Synonyms: Suppressor of cytokine signaling 1 (SOCS-1)|JAK-binding protein (JAB)|STAT-induced STAT inhibitor 1 (SSI-1)|Tec-interacting protein 3 (TIP-3)|SOCS1|SSI1|TIP3
Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
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分子量
- 24 kDa
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基因ID
- 8651
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UniProt
- O15524
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途径
- JAK/STAT Signaling, Interferon-gamma Pathway, TLR signaling, Response to Growth Hormone Stimulus
抗原
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