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14-3-3 sigma/SFN 抗体

Name: 14-3-3 sigma/SFN 抗体
Brand: antibodies-online
SKU: ABIN7119542
Availability: OutOfStock

This anti-14-3-3 sigma/SFN antibody is a 兔多克隆 antibody detecting 14-3-3 sigma/SFN in WB, IHC, ELISA 和 IF. Suitable for 人, 小鼠和大鼠.

产品编号 ABIN7119542

发货至: 中国

Quick Overview for 14-3-3 sigma/SFN 抗体 (ABIN7119542)

抗原

See all 14-3-3 sigma/SFN (SFN) 抗体

14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This 14-3-3 sigma/SFN antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Discover our top product SFN Primary Antibody

纯化方法

Immunogen affinity purified

纯度

≥95 % as determined by SDS-PAGE

免疫原

14-3-3 protein sigma

亚型

IgG
anti-Stratifin (SFN) antibody
SFN 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Stratifin (SFN) (AA 1-248) antibody
SFN 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Stratifin (SFN) (Internal Region) antibody
Verified SFN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Stratifin (SFN) (C-Term) antibody
SFN 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Stratifin (SFN) (AA 1-249) antibody
SFN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated

anti-Stratifin (SFN) (AA 1-248) antibody
SFN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G2 unconjugated

anti-Stratifin (SFN) antibody
SFN 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal CPTC-SFN-2 unconjugated

anti-Stratifin (SFN) (AA 140-156), (Middle Region) antibody
SFN 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Stratifin (SFN) (AA 1-248) antibody
SFN 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Stratifin (SFN) (AA 222-248), (C-Term) antibody
SFN 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB27523 unconjugated

应用备注

WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

-20°C for 12 months (Avoid repeated freeze / thaw cycles.)

有效期

12 months
抗原

14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

别名

SFN

背景

Synonyms:14 3 3 protein sigma, HME1, SFN, stratifin, YWHAS Background:14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.

分子量

31 kDa

基因ID

2810

UniProt

P31947

途径

p53 Pathway, Myometrial Relaxation and Contraction