SSTR2 抗体
Quick Overview for SSTR2 抗体 (ABIN7119337)
抗原
See all SSTR2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SSTR2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- somatostatin receptor 2
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亚型
- IgG
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应用备注
- WB: 1:500-1:1000, IHC: 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SSTR2 (Somatostatin Receptor 2 (SSTR2))
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别名
- SSTR2
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背景
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Synonyms: Somatostatin receptor type 2 (SS-2-R, SS2-R, SS2R, SST2)|SRIF-1|SSTR2
Background: Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
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分子量
- 41 kDa
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基因ID
- 6752
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UniProt
- P30874
抗原
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