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SSTR2 抗体

This anti-SSTR2 antibody is a 兔 多克隆 antibody detecting SSTR2 in WB, ELISA 和 IHC. Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN7119337
发货至: 中国

Quick Overview for SSTR2 抗体 (ABIN7119337)

抗原

See all SSTR2 抗体
SSTR2 (Somatostatin Receptor 2 (SSTR2))

适用

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  • 7
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  • 5
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人, 大鼠, 小鼠

宿主

  • 44
  • 5
  • 2

克隆类型

  • 39
  • 9
  • 2
多克隆

标记

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  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
This SSTR2 antibody is un-conjugated

应用范围

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  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    somatostatin receptor 2

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:1000, IHC: 1:50-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    SSTR2 (Somatostatin Receptor 2 (SSTR2))

    别名

    SSTR2

    背景

    Synonyms:Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Background:Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

    分子量

    41 kDa

    基因ID

    6752

    UniProt

    P30874
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