SSTR2 抗体 (Extracellular, N-Term)
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Quick Overview for SSTR2 抗体 (Extracellular, N-Term) (ABIN7043765)
抗原
See all SSTR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-43, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human- 12,14 amino acid residues identical
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产品特性
- Anti-Somatostatin Receptor Type 2 (extracellular) Antibody is directed against the N-terminal domain of the rat SSTR2. Anti-Somatostatin Receptor Type 2 (extracellular) Antibody (ABIN7043765, ABIN7045268 and ABIN7045269), can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize SSTR2 from mouse, human and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GSNQTEPYYDMTSN, corresponding to amino acid residues 30-43 of rat SSTR2
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亚型
- IgG
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应用备注
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WB: 1:200
FC: 5 mg per reaction
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7237239)
Blocking Peptide: (ABIN7237239)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SSTR2 (Somatostatin Receptor 2 (SSTR2))
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别名
- SSTR2
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背景
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Synonyms: SSTR2, SS2R, Smstr2, SRIF1A
Description: Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner.1,2Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner.2Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors.4In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.
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基因ID
- 54305
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NCBI登录号
- NM_001050
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UniProt
- P30680
抗原
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