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SIX Homeobox 1 抗体

This anti-SIX Homeobox 1 antibody is a 兔 多克隆 antibody detecting SIX Homeobox 1 in WB, ELISA, IF 和 IP. Suitable for 人 和 小鼠.
产品编号 ABIN7119116
发货至: 中国

Quick Overview for SIX Homeobox 1 抗体 (ABIN7119116)

抗原

See all SIX Homeobox 1 (SIX1) 抗体
SIX Homeobox 1 (SIX1)

适用

  • 32
  • 20
  • 14
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠

宿主

  • 28
  • 4

克隆类型

  • 29
  • 3
多克隆

标记

  • 21
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This SIX Homeobox 1 antibody is un-conjugated

应用范围

  • 18
  • 14
  • 6
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    SIX homeobox 1

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    SIX Homeobox 1 (SIX1)

    别名

    SIX1

    背景

    Synonyms:BOS3, DFNA23, Homeobox protein SIX1, Sine oculis homeobox homolog 1, SIX homeobox 1, SIX1, TIP39 Background:Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2(By similarity). Regulates the expression of CCNA1.

    分子量

    32-35 kDa

    基因ID

    6495

    UniProt

    Q15475

    途径

    Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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