SETMAR 抗体
Quick Overview for SETMAR 抗体 (ABIN7118987)
抗原
See all SETMAR 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SETMAR antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- SET domain and mariner transposase fusion gene
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亚型
- IgG
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anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) (AA 1-352) antibody
SETMAR 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) antibodySETMAR 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) (C-Term) antibodyVerified SETMAR 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) antibodySETMAR 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) (N-Term) antibodySETMAR 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) antibodySETMAR 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
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别名
- SETMAR
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背景
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Synonyms: Histone-lysine N-methyltransferase SETMAR|SET domain and mariner transposase fusion protein (Metnase)|SETMAR
Background: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats(TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity(PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining(PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A(PubMed:18790802, PubMed:20457750).
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分子量
- 77 kDa
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基因ID
- 6419
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UniProt
- Q53H47
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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