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- 抗原 See all SETMAR 抗体
- SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SETMAR antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- SETMAR Antibody detects endogenous levels of total SETMAR.
- 预测反应
- Bovine,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SETMAR, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SETMAR Primary Antibody
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anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) (AA 1-352) antibody
SETMAR 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) antibodySETMAR 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) antibodySETMAR 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) (C-Term) antibodyVerified SETMAR 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-SET Domain and Mariner Transposase Fusion Gene (SETMAR) antibodySETMAR 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))
- 别名
- SETMAR (SETMAR 产品)
- 别名
- HsMar1 antibody, METNASE antibody, Mar1 antibody, 5830404F24Rik antibody, Etet2 antibody, SETMAR antibody, zgc:172212 antibody, SET domain and mariner transposase fusion gene antibody, SET domain without mariner transposase fusion antibody, histone-lysine N-methyltransferase SETMAR antibody, SETMAR antibody, Setmar antibody, LOC470738 antibody, setmar antibody, LOC703880 antibody, LOC100447656 antibody, LOC100586616 antibody
- 背景
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Description: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).
Gene: SETMAR
- 分子量
- 78 kDa
- 基因ID
- 6419
- UniProt
- Q53H47
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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