Septin 2 抗体
Quick Overview for Septin 2 抗体 (ABIN7118880)
抗原
See all Septin 2 (SEPT2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SEPTIN2 antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- septin 2
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亚型
- IgG1
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应用备注
- WB: 1:2000-1:20000, IHC: 1:50-1:2000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Septin 2 (SEPT2)
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别名
- SEPTIN2
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背景
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Synonyms: Septin-2|Neural precursor cell expressed developmentally down-regulated protein 5 (NEDD-5)|SEPTIN2|DIFF6|KIAA0158|NEDD5|SEPT2
Background: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex(also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
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分子量
- 43 kDa
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基因ID
- 4735
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UniProt
- Q15019
抗原
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