PSMA7 抗体
Quick Overview for PSMA7 抗体 (ABIN7117915)
抗原
See all PSMA7 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PSMA7 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- proteasome(prosome, macropain) subunit, alpha type, 7
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PSMA7 (Proteasome Subunit alpha 7 (PSMA7))
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别名
- PSMA7
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背景
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Synonyms: Proteasome subunit alpha type-7|Proteasome subunit RC6-1|Proteasome subunit XAPC7|PSMA7|HSPC
Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor(AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
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分子量
- 28-30 kDa
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基因ID
- 5688
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UniProt
- O14818
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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