PSME4 抗体
Quick Overview for PSME4 抗体 (ABIN7117899)
抗原
See all PSME4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PSME4 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- proteasome(prosome, macropain) activator subunit 4
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亚型
- IgG
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anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 1634-1843) antibody
PSME4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 105-198) antibodyPSME4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 503-535) antibodyPSME4 适用: 人 WB 宿主: 兔 Polyclonal RB55279 unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:500-1:1000 , IHC: 1:50-1:500, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
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别名
- PSME4
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背景
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Synonyms: Proteasome activator complex subunit 4|Proteasome activator PA200|PSME4|KIAA0077
Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP-and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like(BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
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分子量
- 140 kDa
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基因ID
- 23198
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UniProt
- Q14997
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途径
- DNA Replication, Synthesis of DNA
抗原
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