PMEPA1 抗体
Quick Overview for PMEPA1 抗体 (ABIN7117874)
抗原
See all PMEPA1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PMEPA1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- prostate transmembrane protein, androgen induced 1
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亚型
- IgG
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anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibody
PMEPA1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PMEPA1-2696 unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 173-252) antibodyPMEPA1 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 181-280) antibodyPMEPA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A12 unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibodyPMEPA1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PMEPA1-2697 unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibodyPMEPA1 适用: 人 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 21-120) antibodyPMEPA1 适用: 人, 小鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibodyPMEPA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 101-150) antibodyPMEPA1 适用: 人 IHC, WB, ELISA, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))
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别名
- PMEPA1
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背景
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Synonyms: Protein TMEPAI|Prostate transmembrane protein androgen induced 1|Solid tumor-associated 1 protein|Transmembrane prostate androgen-induced protein|PMEPA1|STAG1|TMEPAI
Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514).
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分子量
- 32 kDa
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基因ID
- 56937
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UniProt
- Q969W9
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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