PMEPA1 抗体 (AA 21-120)
-
- 抗原 See all PMEPA1 抗体
- PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))
-
抗原表位
- AA 21-120
-
适用
- 人, 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PMEPA1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Sheep,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TMEPAI
- 亚型
- IgG
- Top Product
- Discover our top product PMEPA1 Primary Antibody
-
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibody
PMEPA1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PMEPA1-2696 unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibodyPMEPA1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PMEPA1-2697 unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 181-280) antibodyPMEPA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A12 unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 173-252) antibodyPMEPA1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibodyPMEPA1 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 1268-1341) antibodyPMEPA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) antibodyPMEPA1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) (AA 101-150) antibodyPMEPA1 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
- 抗原
- PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))
- 别名
- TMEPAI (PMEPA1 产品)
- 别名
- Tmepai antibody, PMEPA1 antibody, TMEPAI antibody, zgc:92731 antibody, tmepai antibody, STAG1 antibody, 2210418I02Rik antibody, AW455466 antibody, Erg1.2 antibody, N4wbp4 antibody, Stag1 antibody, prostate transmembrane protein, androgen induced 1 antibody, prostate transmembrane protein, androgen induced 1 L homeolog antibody, Pmepa1 antibody, PMEPA1 antibody, pmepa1 antibody, pmepa1.L antibody
- 背景
-
Synonyms: PMEPA_HUMAN, PMEPA1, Prostate transmembrane protein, androgen induced 1, Solid tumor associated 1 protein, Solid tumor-associated 1 protein, STAG1, TMEPAI, Transmembrane prostate androgen induced protein, Transmembrane prostate androgen-induced protein, Transmembrane, prostate androgen induced RNA.
Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
- 基因ID
- 56937
- UniProt
- Q969W9
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
-
