Notch1 抗体
Quick Overview for Notch1 抗体 (ABIN7116932)
抗原
See all Notch1 (NOTCH1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- Notch homolog 1, translocation-associated(Drosophila)
-
亚型
- IgG
-
-
anti-Notch 1 (NOTCH1) antibody (APC)
NOTCH1 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal mN1A APC
anti-Notch 1 (NOTCH1) antibody (PE)NOTCH1 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal mN1A PE
anti-Notch 1 (NOTCH1) (AA 1919-2079) antibodyNOTCH1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Notch 1 (NOTCH1) (AA 2101-2300) antibodyNOTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Notch 1 (NOTCH1) (Cleaved-Val1754) antibodyNOTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Notch 1 (NOTCH1) (AA 20-216) antibodyNOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 unconjugated
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (HRP)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 HRP
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (FITC)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 FITC
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (Biotin)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 Biotin
anti-Notch 1 (NOTCH1) (AA 20-216) antibody (PE)NOTCH1 适用: 小鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S253-32 PE
-
-
应用备注
- WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
有效期
- 12 months
-
-
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
-
别名
- NOTCH1
-
背景
- Synonyms:lin 12, Mis6, Notch1, Tan1 Background:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone(SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile(sensory) cilia at the left-right organiser(LRO).The antibody is specific to NOTCH1. It can recognize the full length NOTCH1(270 kDa) and all the three cleaved NOTCH1 forms 110-120 kDa.
-
分子量
- 270 kDa,120kd
-
基因ID
- 4851
-
UniProt
- P46531
-
途径
- Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
抗原
-
