MARK2 抗体
Quick Overview for MARK2 抗体 (ABIN7116060)
抗原
See all MARK2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MARK2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- MAP/microtubule affinity-regulating kinase 2
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亚型
- IgG
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anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibody
MARK2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 600-630) antibodyMARK2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (Internal Region) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 600-630), (C-Term) antibodyMARK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2527-2528 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (N-Term) antibodyMARK2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 373-594) antibodyMARK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 1-755) antibodyMARK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibodyMARK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (N-Term) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
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别名
- MARK2
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背景
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Synonyms: Serine/threonine-protein kinase MARK2|ELKL motif kinase 1 (EMK-1)|MAP/microtubule affinity-regulating kinase 2|PAR1 homolog|PAR1 homolog b (Par-1b, Par1b)|MARK2|EMK1
Background: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins(DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
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分子量
- 77-90 kDa
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基因ID
- 2011
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UniProt
- Q7KZI7
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途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
-
