COPS7A 抗体
Quick Overview for COPS7A 抗体 (ABIN7113043)
抗原
See all COPS7A 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- COPS7A antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- COP9 constitutive photomorphogenic homolog subunit 7A(Arabidopsis)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))
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别名
- COPS7A
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背景
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Synonyms: COP9 signalosome complex subunit 7a (SGN7a, Signalosome subunit 7a)|Dermal papilla-derived protein 10|JAB1-containing signalosome subunit 7a|COPS7A|CSN7A|DERP10
Background: Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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分子量
- 30 kDa
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基因ID
- 50813
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UniProt
- Q9UBW8
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途径
- Cell Division Cycle
抗原
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