CHMP4B 抗体
Quick Overview for CHMP4B 抗体 (ABIN7112648)
抗原
See all CHMP4B 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- CHMP4B antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- chromatin modifying protein 4B
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
-
别名
- CHMP4B
-
背景
-
Synonyms: Charged multivesicular body protein 4b|Chromatin-modifying protein 4b (CHMP4b)|SNF7 homolog associated with Alix 1|SNF7-2 (hSnf7-2)|Vacuolar protein sorting-associated protein 32-2 (Vps32-2, hVps32-2)|CHMP4B|C20orf178|SHAX1
Background: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
-
分子量
- 35 kDa
-
基因ID
- 128866
-
UniProt
- Q9H444
抗原
-