CD44 抗体 (AA 28-380)
Quick Overview for CD44 抗体 (AA 28-380) (ABIN7112500)
抗原
See all CD44 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 28-380
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原理
- CD44 antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 28-380aa
Immunogen: CD44 molecule(Indian blood group)
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亚型
- IgG2a
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应用备注
- WB: 1:500-1:5000, IHC: 1:50-1:200, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CD44
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别名
- CD44
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背景
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Synonyms: CD44 antigen|CDw44|Epican|Extracellular matrix receptor III (ECMR-III)|GP90 lymphocyte homing/adhesion receptor|HUTCH-I|Heparan sulfate proteoglycan|Hermes antigen|Hyaluronate receptor|Phagocytic glycoprotein 1 (PGP-1)|Phagocytic glycoprotein I (PGP-I)|CD44|LHR|MDU2|MDU3|MIC4
Background: Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).
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分子量
- 80-95 kDa
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基因ID
- 960
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UniProt
- P16070
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途径
- Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
抗原
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