ATF4 抗体
Quick Overview for ATF4 抗体 (ABIN7111244)
抗原
See all ATF4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ATF4 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- activating transcription factor 4(tax-responsive enhancer element B67)
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亚型
- IgG
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anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 130-347) antibody
ATF4 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 171-270) antibodyATF4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B3 unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 212-351) antibodyATF4 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 2A6F12 unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 251-351) antibodyATF4 适用: 人, 小鼠, 大鼠, 犬, 兔 WB, ELISA, FACS, IF (cc), IHC (p), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) antibodyATF4 适用: 人 WB, IHC, ELISA, IP, IF, FACS 宿主: 兔 Monoclonal 9E1 unconjugated Recombinant Antibody
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (N-Term) antibodyATF4 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (N-Term) antibodyATF4 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (N-Term) antibodyATF4 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 126-291) antibodyATF4 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) (AA 1-351) antibodyATF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
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别名
- ATF4
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背景
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Synonyms: Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4)|Activating transcription factor 4|Cyclic AMP-responsive element-binding protein 2 (CREB-2, cAMP-responsive element-binding protein 2)|Tax-responsive enhancer element-binding protein 67 (TaxREB67)|ATF4|CREB2|TXREB
Background: Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).
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分子量
- 50-58 kDa, 35-38 kDa
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基因ID
- 468
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UniProt
- P18848
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途径
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response
抗原
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