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ATF4 抗体 (N-Term)

ATF4 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2779918
发货至: 中国
  • 抗原 See all ATF4 抗体
    ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
    抗原表位
    • 25
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    N-Term
    适用
    • 158
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    • 23
    • 16
    • 5
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    • 4
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    • 1
    小鼠
    宿主
    • 137
    • 29
    • 1
    克隆类型
    • 129
    • 38
    多克隆
    标记
    • 77
    • 12
    • 9
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    This ATF4 antibody is un-conjugated
    应用范围
    • 130
    • 72
    • 41
    • 27
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    • 22
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    • 9
    • 6
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    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    MALFTKSSSS VAVTDKDTFE LSTFLESSKA PQHDRDELPE QRSVGGGLDD
    预测反应
    Mouse: 100%
    产品特性
    This is a rabbit polyclonal antibody against ATF4. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of mouse ATF4
    Top Product
    Discover our top product ATF4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Antigen size: 381 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ye, Zhang, Ancrum, Manevich, Townsend, Tew: "Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response." in: Antioxidants & redox signaling, (2016) (PubMed).

    Schneeberger, Dietrich, Sebastián, Imbernón, Castaño, Garcia, Esteban, Gonzalez-Franquesa, Rodríguez, Bortolozzi, Garcia-Roves, Gomis, Nogueiras, Horvath, Zorzano, Claret: "Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance." in: Cell, Vol. 155, Issue 1, pp. 172-87, (2013) (PubMed).

    Drivas, Holzbaur, Bennett: "Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration." in: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4525-39, (2013) (PubMed).

    Alger, Rayavarapu, Nagaraju: "Measurement of activation of the endoplasmic reticulum stress response in autoimmune myositis." in: Methods in enzymology, Vol. 489, pp. 207-25, (2011) (PubMed).

  • 抗原
    ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
    别名
    ATF4 (ATF4 产品)
    别名
    CREB-2 antibody, CREB2 antibody, TAXREB67 antibody, TXREB antibody, ATF4 antibody, atf-4 antibody, creb-2 antibody, creb2 antibody, taxreb67 antibody, txreb antibody, atf4 antibody, wu:fj01c08 antibody, wu:fk30b04 antibody, zgc:85951 antibody, sb:eu681 antibody, wu:fb08f07 antibody, zgc:171702 antibody, Atf-4 antibody, C/ATF antibody, ATF4-I antibody, atf4-a antibody, atf4-b antibody, atf4-ii antibody, activating transcription factor 4 antibody, activating transcription factor 4 L homeolog antibody, activating transcription factor 4a antibody, activating transcription factor 4b antibody, activating transcription factor 4 S homeolog antibody, ATF4 antibody, atf4 antibody, Atf4 antibody, atf4.L antibody, atf4a antibody, atf4b antibody, atf4.S antibody
    背景
    Atf4 binds to asymmetric cAMP response elements (CRE) as a heterodimer and to palindromic CRE's as a homodimer.
    Alias Symbols: Atf-4, C/ATF, CREB2, TAXREB67
    Protein Interaction Partner: Egln3, Ubc, Hif1a, Satb2, Fam175b, Trib3, Gabbr2, Gabbr1, Jun, Fos, Dapk3, Rps6ka3, Tnfsf11, Prkaca,
    Protein Size: 381
    分子量
    42 kDa
    基因ID
    11911
    NCBI登录号
    NM_009716, NP_033846
    UniProt
    Q61328
    途径
    Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response
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