RNF4 抗体
Our Local Distributor
北京 101111
Quick Overview for RNF4 抗体 (ABIN7091651)
抗原
See all RNF4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
预测反应
- Human
-
免疫原
- Recombinant human RNF4.
-
-
anti-Ring Finger Protein 4 (RNF4) (AA 1-103) antibody
RNF4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 1-190) antibodyRNF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 107-190) antibodyRNF4 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 95-123) antibodyRNF4 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 4 (RNF4) (AA 94-123), (C-Term) antibodyRNF4 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:300-5000
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 μg/μL
-
缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
有效期
- 12 months
-
-
- RNF4 (Ring Finger Protein 4 (RNF4))
-
别名
- RNF4
-
背景
-
Synonyms: RNF4_HUMAN, E3 ubiquitin ligase RNF4, E3 ubiquitin protein ligase RNF4, Protein SNURF, RES4 26, RING finger protein 4, SLX5, Small nuclear ring finger protein, SNURF.
Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
-
基因ID
- 6047
-
UniProt
- P78317
-
途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
-
