Recombinant MSH2 抗体
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北京 101111
Quick Overview for Recombinant MSH2 抗体 (ABIN7091416)
抗原
See all MSH2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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原理
- MSH2 Recombinant Antibody
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MSH2
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亚型
- IgG
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anti-Mismatch Repair Protein 2 (MSH2) (AA 327-427) antibody
MSH2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Hamster WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal MSH2-2622 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人, 小鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2E2C7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibodyMSH2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibodyMSH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibodyMSH2 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibodyMSH2 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal 6B4F7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibodyMSH2 适用: 人, 犬 IHC 宿主: 小鼠 Monoclonal SYP-3551 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (C-Term) antibodyMSH2 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4F10D6 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibodyMSH2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4B2 unconjugated
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应用备注
- WB(WB(1:1000-5000)), FCM(FCM(1:50-100)), IHC-P(IHC-P(1:200-1000)), IHC-F(IHC-F(1:200-1000)), IF(IHC-P)(IF(IHC-P)(1:200-1000)), IF(ICC)(IF(ICC)(1:50-200))
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 12 months
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- MSH2 (Mismatch Repair Protein 2 (MSH2))
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别名
- MSH2
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背景
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Synonyms: MSH-2, BAT26, DNA mismatch repair protein Msh2, FCC1, COCA1, HNPCC, LCFS2, HNPCC1, BAT26, COCA 1, COCA1, DNA mismatch repair protein Msh2, FCC 1, FCC1, hMSH2, HNPCC 1, HNPCC, HNPCC1, LCFS2, MSH 2, Msh2, MSH2_HUMAN, MutS homolog 2, MutS homolog 2 colon cancer nonpolyposis type 1, MutS protein homolog 2.
Background: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
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基因ID
- 4436
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UniProt
- P43246
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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