PD-1 抗体 (APC-iFluor™700)
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- 抗原 See all PD-1 (PDCD1) 抗体
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PD-1 antibody is conjugated to APC-iFluor™700
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应用范围
- Flow Cytometry (FACS)
- 纯度
- >95 %
- 质量等级
- GMP Grade
- 免疫原
- PD1 transfected HEK293 cells
- 克隆位点
- 8G10
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product PDCD1 Primary Antibody
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- 应用备注
- FC: 5 µL/test We recommend that every lab carries out an initial titration study before running your samples to ensure that the optimal concentration is selected for your application.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS, pH 7.2, 0.09 % sodium azide and 0.2 % (w/v) BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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- 抗原
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- 别名
- PD1 (PDCD1 产品)
- 别名
- CD279 antibody, PD-1 antibody, PD1 antibody, SLEB2 antibody, hPD-1 antibody, hPD-l antibody, Ly101 antibody, Pdc1 antibody, programmed cell death 1 antibody, PDCD1 antibody, Pdcd1 antibody
- 背景
- The clone 8G10, a mouse monoclonal antibody selectively binds with a 50-55 kD cell surface protein commonly known as Programmed cell death 1 (PD-1) or CD279, a member of the immunoglobulin superfamily. PD-1 expression is mostly observed in activated T cells and B cells, and also in dendritic cells. PD-1 signals via binding its two ligands, PD-L1 and PD-L2. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T cell death. Blocking of PD-1 by its antibody restores T cells immunity against tumor and infectious agents. PD-1-blockade based immunotherapy is, therefore, highly clinically useful against various types of cancers and infectious diseases.
- 基因ID
- 5133
- UniProt
- Q15116
- 途径
- Cancer Immune Checkpoints
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