p130 抗体
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北京 101111
Quick Overview for p130 抗体 (ABIN7075406)
抗原
See all p130 (RBL2) 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse Rb2 p130
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应用备注
- IHC/IF (M,R) 1:500-1:1500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
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别名
- Rb2 p130
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背景
- RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
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基因ID
- 19651
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NCBI登录号
- NP_001268929
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UniProt
- Q64700
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途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
抗原
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