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Recombinant LAG3 抗体

LAG3 适用: 小鼠 IP, FACS, BP 宿主: 大鼠 Monoclonal C9B7W unconjugated Recombinant Antibody
产品编号 ABIN7072736
发货至: 中国
  • 抗原 See all LAG3 抗体
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    抗体类型
    Recombinant Antibody
    适用
    • 101
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    小鼠
    宿主
    • 58
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    大鼠
    克隆类型
    • 55
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    单克隆
    标记
    • 66
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    This LAG3 antibody is un-conjugated
    应用范围
    • 79
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    Immunoprecipitation (IP), Flow Cytometry (FACS), Blocking Peptide (BP)
    原理
    Anti-LAG-3 [C9B7W], Rat IgG1, kappa
    特异性
    This antibody is specific for an epitope in the D2 domain of murine LAG-3.
    产品特性

    Original Species of Ab: Rat

    Original Format of Ab: IgG1

    纯化方法
    Protein A affinity purified
    免疫原
    This antibody was raised by immunising Lewis rats with a murine LAG-3:Ig fusion protein.
    克隆位点
    C9B7W
    亚型
    IgG1 kappa
    Top Product
    Discover our top product LAG3 Primary Antibody
  • 应用备注
    This antibody has been used in flow cytometric analysis of splenocytes (Workman et al, 2005), T cell hybridomas expressing wild-type or chimeric CD4:murine LAG-3 (Workman et al, 2002) and CD4+ regulatory T cells (Chien et al, 2017). It has also been used in immunoprecipitation analysis of murine T hybridoma 3A9 cells transduced with murine LAG-3 (Li et al, 2004). This antibody blocks LAG-3 function in vitro, inhibiting antigen-induced IL-2 production in LAG-3-expressing T cell hybridomas, but does not block LAG-3:MHC class II interaction (Workman et al, 2002). Treatment with this antibody also blocks LAG-3 function in vivo, leading to accelerated homeostatic expansion of WT T cells (Workman et al, 2005). Administration of this LAG-3-blocking antibody, in combination with PD-L1 blockade, synergistically improves the survival of lymphodepleted myeloma-bearing mice (Jing et al, 2015).
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % Proclin 300.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    别名
    Lag3 (LAG3 产品)
    背景
    CD223, LAG3, Lymphocyte activation gene 3 protein
    UniProt
    Q61790
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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