Recombinant Integrin beta 2 抗体
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Quick Overview for Recombinant Integrin beta 2 抗体 (ABIN7072727)
抗原
See all Integrin beta 2 (ITGB2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-CD18 [60.3], Rabbit IgG, kappa
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特异性
- This antibody binds the CD18 component of the β-2 integrin family which is expressed by leukocytes and neutrophils.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing BALB/c mice with alloantigen activated T cells.
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亚型
- IgG kappa
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anti-Integrin beta 2 (ITGB2) antibody
ITGB2 适用: 人 FACS, WB, IP, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal MEM-48 unconjugated
anti-Integrin beta 2 (ITGB2) antibodyITGB2 适用: 人 FACS, WB, IP, Func, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal MEM-48 unconjugated
anti-Integrin beta 2 (ITGB2) (AA 70-170) antibodyITGB2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 2 (ITGB2) antibody (Biotin)ITGB2 适用: 人 FACS, WB, IP, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal MEM-48 Biotin
anti-Integrin beta 2 (ITGB2) antibody (FITC)ITGB2 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-48 FITC
anti-Integrin beta 2 (ITGB2) antibody (PE)ITGB2 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-48 PE
anti-Integrin beta 2 (ITGB2) antibodyITGB2 适用: 小鼠 FACS, WB, IP, Func, IHC (fro), IHC (p) 宿主: 大鼠 Monoclonal M18-2 unconjugated
anti-Integrin beta 2 (ITGB2) (AA 559-700) antibodyITGB2 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 3C11G5 unconjugated
anti-Integrin beta 2 (ITGB2) (AA 17-382) antibodyITGB2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 2 (ITGB2) (AA 701-770) antibodyITGB2 适用: 人, 大鼠 ELISA, IHC (fro), ICC, IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- This antibody is capable of inhibiting several cell mediated immune functions. It inhibits proliferative responses of T cells stimulated by soluble antigens, mitogens, or allogeneic cells in the initiation of a culture, but not when added after 48 hours. It successfully blocks the lytic activity of cytotoxic T cells and natural killer cells and the migration of neutrophilic granulocytes (PMID: 6644024). This antibody inhibits phagocytosis by reaction with the C3bi receptor, and stimulates phagocytosis by reverse opsonization (PMID: 3880787). This antibody inhibits aggregation of neutrophils in response phorbol myristate acetate, zymosan-activated plasma, and N-formyl-methionylleucylphenylalanine in a dose dependent manner (PMID: 3995185). 60.3 also inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo (PMID: 3539230). 60.3 successfully inhibits neutrophil function in vivo and has the potential to be used as an anti-inflammatory agent (PMID: 3693901). This antibody has application in blocking neutrophil mediated organ damage which occurs after myocardial infarct or hemorrhagic shock. Humanized version of this antibody binds CD18 with a 4-fold less affinity than its parent murine version (PMID: 7937713).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Integrin beta 2 (ITGB2)
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别名
- CD18
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背景
- ITGB2, MFI7, Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150.95 subunit beta, Complement receptor C3 subunit beta, β2-subunit of leukocyte integrins
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UniProt
- P05107
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途径
- NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
抗原
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