Recombinant IL-6 Receptor 抗体
Quick Overview for Recombinant IL-6 Receptor 抗体 (ABIN7072548)
抗原
See all IL-6 Receptor (IL6R) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-IL-6R [D7715A7], Rabbit IgG, kappa
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特异性
- This antibody is specific for murine IL-6R.
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产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG2b
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was raised by immunising Lewis rats with OKT4 cells.
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亚型
- IgG kappa
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anti-Interleukin 6 Receptor (IL6R) antibody
IL6R 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 20-320) antibodyIL6R 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 216-356) antibodyIL6R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) antibodyIL6R 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 1-468) antibodyIL6R 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 205-347) antibodyIL6R 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 385-462) antibodyIL6R 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 1-468) antibodyIL6R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 21-120) antibodyIL6R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G6 unconjugated
anti-Interleukin 6 Receptor (IL6R) (AA 21-120) antibodyIL6R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E11 unconjugated
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应用备注
- This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990, Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60 % and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
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别名
- IL-6R
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背景
- CD126, 15A7, IL-6Ra, IL6R, Interleukin-6 receptor subunit alpha, Il6ra, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1
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UniProt
- P22272
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途径
- JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
抗原
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