Recombinant HVEM 抗体
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- 抗原 See all HVEM (TNFRSF14) 抗体
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- 抗体类型
- Recombinant Antibody
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- Chimeric
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标记
- This HVEM antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Peptide (BP), Functional Studies (Func)
- 原理
- Anti-HVEM [HMHV-1B18], Rabbit IgG, kappa
- 特异性
- This antibody is specific for Herpes Virus Entry Mediator (HVEM, TR2), a type I transmembrane protein of TNF-receptor superfamily. This receptor, which is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. HVEM has also been demonstrated to be a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
- 产品特性
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Original Species of Ab: Hamster, Armenian
Original Format of Ab: IgG
- 纯化方法
- Protein A affinity purified
- 免疫原
- This antibody was raised by immunising Armenian hamsters with mouse HVEM:Fc fusion protein.
- 克隆位点
- HMHV-1B18
- 亚型
- IgG kappa
- Top Product
- Discover our top product TNFRSF14 Primary Antibody
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 38-283) antibody
TNFRSF14 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2G6-2C7 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 41-209) antibodyTNFRSF14 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 1-283) antibodyTNFRSF14 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 38-284) antibodyTNFRSF14 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2G6-2C7 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (C-Term) antibodyTNFRSF14 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (Internal Region) antibodyVerified TNFRSF14 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) antibodyTNFRSF14 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM131 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 210-236) antibodyTNFRSF14 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21524 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 216-245), (Middle Region) antibodyTNFRSF14 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 269-302), (C-Term) antibodyTNFRSF14 适用: 人 WB 宿主: 兔 Polyclonal RB52847 unconjugated
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- 应用备注
- This antibody has been used in FACS to demonstrate that lymphatic endothelial cells mediate deletion only via programmed cell death-1 (PD-1) ligand 1 (Tewalt et al 2012) and in Western Blot to study the role of LIGHT in the pathogenesis of hepatitis (Anand et al 2006). This antibody has been also been used in vivo experiments to study the mechanisms by which TNFSF14 functions to promote airway remodelling in asthma (Sibilano et al 2016), to confirm that costimulatory role through HVEM is not necessary for LIGHT-mediated liver inflammation (Anand et at 2006), and to investigate the role that herpesvirus entry mediator plays in the development of experimental conjunctivitis (Ishida et al, 2012). Treatment with this antibody has been observed to diminish plasma levels of antigen-specific IgG1 and IgE antibodies in mouse asthma models (Sibilano et al 2016), to interfere with the LIGHT-HVEM interaction but not interaction between B and T lymphocyte attenuator (BTLA) and HVEM in mouse hepatitis models (Anand et at 2006), and NOT to affect the development of experimental conjunctivitis in either the induction or the effector phase (Ishida et al, 2012).
- 说明
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This is a chimeric antibody made using the variable domain sequences of the original hamster (Armenian) antibody format. It was created to improve compatibility with existing reagents, assays, and techniques.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % Proclin 300.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- 抗原
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- 别名
- HVEM (TNFRSF14 产品)
- 物质类
- Viral Protein
- 背景
- CD270, TNF Receptor-like 2, ATAR, Herpes virus Entry Mediator A, HVEA, Herpes virus Entry Mediator, LIGHTR, Tumor Necrosis Factor Receptor-Like Gene2, Tumor Necrosis Factor Receptor-Like 2, TR2, Tumor Necrosis Factor Receptor Superfamily Member 14, TNFRSF14, CD40-Like Protein
- UniProt
- Q71F55
- 途径
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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