SYN1 抗体 (Intracellular)
Quick Overview for SYN1 抗体 (Intracellular) (ABIN7043786)
抗原
See all SYN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 234-245, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Synapsin I
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特异性
- Intracellular, region C
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Synapsin I (SYN1) Antibody is directed against an epitope of rat Synapsin I. Anti-Synapsin I (SYN1) Antibody (ABIN7043786, ABIN7044658 and ABIN7044659) can be used in western blot and immunohistochemistry applications. It has been designed to recognize Synapsin I from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RLHKKLGTEEFP(G), corresponding to amino acid residues 234 - 245 of rat Synapsin-1
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亚型
- IgG
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anti-Synapsin I (SYN1) (AA 362-511) antibody
SYN1 适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 7H10G6 unconjugated
anti-Synapsin I (SYN1) (AA 113-420) antibodySYN1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (AA 362-450) antibodySYN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H1 unconjugated
anti-Synapsin I (SYN1) (pSer9) antibodySYN1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer9) antibodySYN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer9) antibodySYN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) antibodySYN1 适用: 人, 大鼠, 小鼠, Cow WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer62), (pSer67) antibodySYN1 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (pSer549) antibodySYN1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin I (SYN1) (AA 201-300) antibodySYN1 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7237307)
Blocking Peptide: (ABIN7237307)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SYN1 (Synapsin I (SYN1))
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别名
- SYN1
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背景
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Synapsin-1,Synapsins are a family of synaptic vesicle associated phosphoproteins consisting of three members: SYN1, SYN2, and SYN3, with several alternative splicing leading to 10 different isoforms. They are involved in synaptic transmission and plasticity, several stages of neurodevelopment, such as axon outgrowth and synapse formation. Synapsins are localized in presynaptic nerve terminals of central neurons1.Synapsin I is a peripheral membrane protein of synaptic vesicles that is phosphorylated at least at three different sites by various protein kinases. All synapsins have a single phosphorylation site in the short N-terminal domain A (site 1) that regulates neurite elongation and synaptic vesicle mobilization2.Synapsin I exhibits an asymmetric structure and exists in two forms, designated synapsin Ia and synapsin Ib. The primary structure of synapsin I is highly conserved, 95 % of the protein's residues are invariant and contain two major structural domains. The protein is divided into a hydrophobic, collagenase resistant head region and a proline rich, collagenase sensitive tail3,4. Synapsin I has been suggested to play an important role in the regulation of neurotransmitter release and the organization of cytoskeletal organization including actin filaments, microtubules and spectrin in the presynaptic terminal5.In vitro studies show that the dephospho-form of synapsin I binds synaptic vesicles, binds and bundles F-actin, and promotes G actin polymerization5.
Alternative names: Synapsin I (SYN1), Synapsin-1 -
基因ID
- 24949
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NCBI登录号
- NM_006950
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UniProt
- P09951
抗原
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