SLC5A8 抗体 (Intracellular)
Quick Overview for SLC5A8 抗体 (Intracellular) (ABIN7043734)
抗原
See all SLC5A8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 544-558, Intracellular
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原理
- A Rabbit Polyclonal Antibody to SMCT1 (SLC5A8) Transporter
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特异性
- Intracellular, C-terminus.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 13 out of 15 amino acid residues identical
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产品特性
- Anti-SMCT1 (SLC5A8) Antibody (ABIN7043734, ABIN7044495 and ABIN7044496) is a highly specific antibody directed against an epitope of the human SLC5A8. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SLC5A8 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: Peptide (C)NGSRAPDHDVTQERDE, corresponding to amino acid residues 15-30 of mouse beta-2-Adrenoceptor
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亚型
- IgG
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anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) (AA 548-574), (C-Term) antibody
SLC5A8 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40849 unconjugated
anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) (Middle Region) antibodySLC5A8 适用: 人, 小鼠, 大鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) (AA 301-400) antibodySLC5A8 适用: 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) (AA 540-610) antibodySLC5A8 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) (AA 579-609) antibodySLC5A8 适用: 人 WB 宿主: 兔 Polyclonal RB54852 unconjugated
anti-Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8) (AA 431-480) antibodySLC5A8 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7237129)
Blocking Peptide: (ABIN7237129)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))
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别名
- SLC5A8
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背景
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Sodium-Coupled Monocarboxylate Transporter 1, Solute Carrier Family 5 Member 8, Apical Iodide Transporter, AIT,Sodium-coupled monocarboxylate transporter 1, SLC5A8, is an electrogenic sodium (Na+) and chloride (Cl-)-dependent sodium-coupled solute transporter that belongs to the Na+/glucose co-transporter gene family (SLC5) 1.It is expressed in the colon, ileum, kidney and thyroid gland and it is involved in the transport of a variety of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate) 1.SLC5A8 was found to be silenced in colon cancer, gastric cancer and possibly other cancer types and hence it is a candidate tumor suppressor gene. This is probably mediated through its role in transforming butyrate, a metabolite that is related to these types of cancer 2.The structure of SLC5A8 was predicted based on its homology to sodium-iodide symporter (NIS) and on the fact that it is a part of the Solut Sodium Symporter (SSS) protein family. The structure contains 13 α-helical TM segments, with the N-terminus facing the extracellular medium and the C-terminus facing the cytoplasm, and a conserved sodium binding site 3.
Alternative names: Sodium-Coupled Monocarboxylate Transporter 1, Solute Carrier Family 5 Member 8, Apical Iodide Transporter, AIT -
基因ID
- 160728
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NCBI登录号
- NM_145913
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UniProt
- Q8N695
抗原
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