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- 抗原 See all NFASC 抗体
- NFASC (Neurofascin (NFASC))
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抗原表位
- AA 1142-1155, Intracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NFASC antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to Neurofascin
- 特异性
- Intracellular, C-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-Neurofascin Antibody (ABIN7043360, ABIN7044538 and ABIN7044539) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize NFASC from human, mouse, and rat samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)REKKDVPLGPEDPK, corresponding to amino acid residues 1142-1155 of rat NFASC
- 亚型
- IgG
- Top Product
- Discover our top product NFASC Primary Antibody
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anti-Neurofascin (NFASC) (AA 501-650) antibody
NFASC 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neurofascin (NFASC) (AA 830-1100) antibodyNFASC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neurofascin (NFASC) (AA 661-758) antibodyNFASC 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Neurofascin (NFASC) (C-Term) antibodyNFASC 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurofascin (NFASC) (AA 760-1007) antibodyNFASC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:800
- 说明
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Negative Control: (ABIN7236045)
Blocking Peptide: (ABIN7236045)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- NFASC (Neurofascin (NFASC))
- 别名
- NFASC (NFASC 产品)
- 背景
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NFASC, NRCAML, NF,Neurofascin belongs to the L1 subgroup of the immunoglobulin superfamily of cell adhesion molecules and is an axon associated surface glycoprotein implicated in axonal growth and fasciculation.Neurofascin is comprised of four structural elements: At the NH2 terminus, neurofascin contains six Ig-like motifs of the C2 subcategory followed by four fibronectin type III (FNIII)-related repeats. Between the FNIII-like repeats and the plasma membrane spanning region, neurofascin contains a 75-amino acid residues rich in proline, alanine and threonine which might be the target of extensive O-linked glycosylation. A transmembrane segment is followed by a 113-amino acid residues-long cytoplasmic domain1.Neurofascin associates with sodium channel β1 (NaVβ1) units via interaction of its first Ig-like domain and second fibronectin type III-like domain with the extracellular Ig-like domain of β1. NaVβ1 subunits localize to nodes of Ranvier with neurofascin in sciatic nerve axons. NaVβ1 and neurofascin are associated as early as postnatal day 5, during the period that nodes of Ranvier are in formation2.Unlike L1 and other subgroup members, neurofascin is subjected to extensive alternative splicing that is regulated during embryonic development of the brain. An oligodendroglial isoform of neurofascin, NF155, serves as a glial receptor for the paranodin/Caspr-contactin complex. The extracellular domain of NF155 binds to the complex at the cell surface3.
Alternative names: Neurofascin, NFASC, NRCAML, NF - 基因ID
- 116690
- NCBI登录号
- NM_001005388
- UniProt
- P97685
- 途径
- Cell-Cell Junction Organization
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