Neuregulin 3 抗体 (Extracellular, N-Term)
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Quick Overview for Neuregulin 3 抗体 (Extracellular, N-Term) (ABIN7043356)
抗原
See all Neuregulin 3 (NRG3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 167-180, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuregulin-3
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Human,rat - identical
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产品特性
- Anti-NRG3 (extracellular) Antibody (ABIN7043356, ABIN7044722 and ABIN7044723) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize Neuregulin-3 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RFPGHRVPIRASPR, corresponding to amino acid residues 167-180 of mouse Neuregulin-3
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亚型
- IgG
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anti-Neuregulin 3 (NRG3) (Internal Region) antibody
NRG3 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (Internal Region) antibodyNRG3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) antibodyNRG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (AA 688-717) antibodyNRG3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2201 unconjugated
anti-Neuregulin 3 (NRG3) (AA 305-336) antibodyNRG3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1279-1280 unconjugated
anti-Neuregulin 3 (NRG3) (AA 540-589) antibodyNRG3 适用: 人, 小鼠, 大鼠, 犬, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) antibodyNRG3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Neuregulin 3 (NRG3) antibodyNRG3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB3810 unconjugated Recombinant Antibody
anti-Neuregulin 3 (NRG3) (AA 351-450) antibodyNRG3 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (C-Term) antibodyVerified NRG3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236034)
Blocking Peptide: (ABIN7236034)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuregulin 3 (NRG3)
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别名
- NRG3
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背景
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Synonyms: Neuregulin-3, HRG3
Description: Neuregulins (NRGs) are single-pass membrane proteins belonging to a multi member family of epidermal growth factor (EGF)-like signaling molecules involved in cell-cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 with multiple isoforms through alternative splicing1.Neuregulin 3 (NRG3) plays a key role in the embryonic cerebral cortex development by regulating the migration and patterning of neural progenitor cells. It specifically binds to the ErbB4 receptor tyrosine kinase in the developing mammalian forebrain2,3.Neuregulin 3 is almost exclusively expressed in the nervous system with highest expression in the anterior cingulate and frontal cortex3,4.Mutations in the neuregulin 3 gene are linked to different mental disorders accompanied with cognitive and behavioral abnormalities such as developmental delay, cognitive impairment, and psychiatric illness2,3. Single nucleotide polymorphisms are associated with delusions in patients with schizophrenia and linked to the disease itself. Knockout mice display novelty-induced hyperactivity and are deficient fear conditioning4.
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基因ID
- 18183
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NCBI登录号
- NM_001010848
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UniProt
- O35181
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途径
- RTK signaling
抗原
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