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- 抗原 See all Neuregulin 3 (NRG3) 抗体
- Neuregulin 3 (NRG3)
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抗原表位
- AA 167-180, Extracellular
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Neuregulin 3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- A Rabbit Polyclonal Antibody to Neuregulin-3
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Human,rat - identical
- 产品特性
- Anti-NRG3 (extracellular) Antibody (ABIN7043356, ABIN7044722 and ABIN7044723) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize Neuregulin-3 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RFPGHRVPIRASPR, corresponding to amino acid residues 167-180 of mouse Neuregulin-3
- 亚型
- IgG
- Top Product
- Discover our top product NRG3 Primary Antibody
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anti-Neuregulin 3 (NRG3) (Internal Region) antibody
NRG3 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (Internal Region) antibodyNRG3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) antibodyNRG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (AA 540-589) antibodyNRG3 适用: 人, 小鼠, 大鼠, 犬, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (AA 688-717) antibodyNRG3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2201 unconjugated
anti-Neuregulin 3 (NRG3) (AA 305-336) antibodyNRG3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1279-1280 unconjugated
anti-Neuregulin 3 (NRG3) (AA 351-450) antibodyNRG3 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (C-Term) antibodyNRG3 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (C-Term) antibodyVerified NRG3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neuregulin 3 (NRG3) (Middle Region) antibodyNRG3 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7236034)
Blocking Peptide: (ABIN7236034)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Neuregulin 3 (NRG3)
- 别名
- NRG3 (NRG3 产品)
- 背景
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Neuregulin-3, HRG3,Neuregulins (NRGs) are single-pass membrane proteins belonging to a multi member family of epidermal growth factor (EGF)-like signaling molecules involved in cell-cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 with multiple isoforms through alternative splicing1.Neuregulin 3 (NRG3) plays a key role in the embryonic cerebral cortex development by regulating the migration and patterning of neural progenitor cells. It specifically binds to the ErbB4 receptor tyrosine kinase in the developing mammalian forebrain2,3.Neuregulin 3 is almost exclusively expressed in the nervous system with highest expression in the anterior cingulate and frontal cortex3,4.Mutations in the neuregulin 3 gene are linked to different mental disorders accompanied with cognitive and behavioral abnormalities such as developmental delay, cognitive impairment, and psychiatric illness2,3. Single nucleotide polymorphisms are associated with delusions in patients with schizophrenia and linked to the disease itself. Knockout mice display novelty-induced hyperactivity and are deficient fear conditioning4.
Alternative names: NRG3, Neuregulin-3, HRG3 - 基因ID
- 18183
- NCBI登录号
- NM_001010848
- UniProt
- O35181
- 途径
- RTK signaling
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