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NGFR 抗体 (Intracellular, Juxtamembrane Domain)

The 兔多克隆 anti-NGFR antibody is suitable to detect NGFR in samples from 人. It has been validated for WB, IHC 和 IF.

Expression of p75NTR in mouse hippocampus - Immunohistochemical staining of mouse frozen hippocampal sections using Anti-p75 NGF Receptor (intracellular) Antibody (ABIN7043348, ABIN7044763 and ABIN7044764) (1:200). (NGFR 抗体 (Intracellular, Juxtamembrane Domain))

IHC

Western blot analysis of rat brain membranes: - 1. (NGFR 抗体 (Intracellular, Juxtamembrane Domain))

3 images

产品编号 ABIN7043348

发货至: 中国

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Quick Overview for NGFR 抗体 (Intracellular, Juxtamembrane Domain) (ABIN7043348)

抗原

See all NGFR 抗体

NGFR (Nerve Growth Factor Receptor (NGFR))

适用

人

宿主

兔

克隆类型

多克隆

标记

This NGFR antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product NGFR Primary Antibody

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AA 278-293, Intracellular, Juxtamembrane Domain

原理

A Rabbit Polyclonal Antibody to Human Neurotrophin Receptor p75NTR

交叉反应

人, 小鼠, 大鼠

预测反应

Mouse,rat - identical

产品特性

Anti-p75 NGF Receptor (intracellular) Antibody is directed against an epitope of human p75NTR. Anti-p75 NGF Receptor (intracellular) Antibody (ABIN7043348, ABIN7044763 and ABIN7044764) can be used in western blot and immunohistochemistry applications. It has been designed to recognize p75NTR from human, mouse and rat samples.

纯化方法

Affinity purified on immobilized antigen.

免疫原

CKQNKQGANSRPVNQT corresponding to amino acid residues 278-293 of human p75NTR

亚型

IgG
anti-Nerve Growth Factor Receptor (NGFR) (AA 301-400) antibody
NGFR 适用: 人, 大鼠, 小鼠 WB, FACS, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nerve Growth Factor Receptor (NGFR) (AA 281-421) antibody
NGFR 适用: 人 IHC 宿主: 小鼠 Monoclonal NGFR-1964 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) (AA 188-203), (Extracellular), (Stalk Region) antibody
KO Validated NGFR 适用: 人 WB, IHC, IF, FACS, IP, IC, LCI 宿主: 兔 Polyclonal unconjugated

anti-Nerve Growth Factor Receptor (NGFR) (AA 281-421) antibody
NGFR 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal rNGFR-1965 unconjugated Recombinant Antibody

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人, 大鼠, Non-Human Primate, 兔 WB, IHC 宿主: 兔 Monoclonal NGFR-1997R unconjugated Recombinant Antibody

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 2F1C2 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人, Non-Human Primate, 兔, Cat, 雪貂 WB, FACS, IHC (p), IP, ICC, ICFC, MS 宿主: 小鼠 Monoclonal NGFR5 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 小鼠 Monoclonal 8G3G10 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人, 兔, Cat, 雪貂, 猴, Baboon IHC, IF, FACS 宿主: 小鼠 Monoclonal NGFR5 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) (AA 281-421) antibody
NGFR 适用: 人 WB, IHC 宿主: 兔 Monoclonal NGFR-2550R unconjugated Recombinant Antibody

应用备注

WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user

说明

Cited Application: IP|IHC
Negative Control: (ABIN7236006)
Blocking Peptide: (ABIN7236006)

限制

仅限研究用
状态

Lyophilized

溶解方式

25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

浓度

0.8 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

NGFR (Nerve Growth Factor Receptor (NGFR))

别名

NGFR

背景

Synonyms: p75NTR, p75 Neurotrophin receptor, Low affinity NGF receptor, TNFR superfamily member 16, TNFRSF16, CD271
Description: The p75 neurotrophin receptor (p75NTR) is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain. p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.As it name implies, p75NTR binds all the neurotrophins (NGF, BDNF, NT-3 and NT-4) with similar nM affinities. Co-expression of p75NTR with the Trk receptors enhances the ability to bind and respond to the specific neurotrophin and induces cell survival. On the other hand, it has recently been demonstrated that p75NTR binds with high affinity to the unprocessed form of NGF (proNGF) probably as a complex with sortilin and this leads to cell death by apoptosis. Finally, a multimeric complex of p75NTR and Nogo receptor binds myelin proteins such as Nogo-66, MAG and OmgP resulting in inhibition of axonal growth.

基因ID

4804

NCBI登录号

NM_002507

UniProt

P08138

途径

NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding