NGFR 抗体
Our Local Distributor
北京 101111
Quick Overview for NGFR 抗体 (ABIN7044625)
抗原
See all NGFR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- A Mouse Monoclonal Antibody to Rat Neurotrophin Receptor p75NTR
-
交叉反应 （详细）
- 192-IgG reacts with rat p75NTR. It does not cross-react with p75NTR of human or mouse origin.
-
预测反应
- Recognizes p75NTR from rat samples only
-
产品特性
- Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (ABIN7043342, ABIN7044624, ABIN7044625 and ABIN7044626) is a highly specific monoclonal antibody directed against p75NTR. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize p75NTR from rat samples only.
-
纯化方法
- Affinity purified from cultured hybridoma medium.
-
免疫原
- Solubilized proteins from PC12 membranes.
-
亚型
- IgG1
-
-
anti-Nerve Growth Factor Receptor (NGFR) (AA 301-400) antibody
NGFR 适用: 人, 大鼠, 小鼠 WB, FACS, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (NGFR) (AA 281-421) antibodyNGFR 适用: 人 IHC 宿主: 小鼠 Monoclonal NGFR-1964 unconjugated
anti-Nerve Growth Factor Receptor (NGFR) (AA 188-203), (Extracellular), (Stalk Region) antibodyKO Validated NGFR 适用: 人 WB, IHC, IF, FACS, IP, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (NGFR) (AA 281-421) antibodyNGFR 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal rNGFR-1965 unconjugated Recombinant Antibody
anti-Nerve Growth Factor Receptor (NGFR) antibodyNGFR 适用: 人, 大鼠, Non-Human Primate, 兔 WB, IHC 宿主: 兔 Monoclonal NGFR-1997R unconjugated Recombinant Antibody
anti-Nerve Growth Factor Receptor (NGFR) antibodyNGFR 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 2F1C2 unconjugated
anti-Nerve Growth Factor Receptor (NGFR) antibodyNGFR 适用: 人, Non-Human Primate, 兔, Cat, 雪貂 WB, FACS, IHC (p), IP, ICC, ICFC, MS 宿主: 小鼠 Monoclonal NGFR5 unconjugated
anti-Nerve Growth Factor Receptor (NGFR) antibodyNGFR 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 小鼠 Monoclonal 8G3G10 unconjugated
anti-Nerve Growth Factor Receptor (NGFR) antibodyNGFR 适用: 人, 兔, Cat, 雪貂, 猴, Baboon IHC, IF, FACS 宿主: 小鼠 Monoclonal NGFR5 unconjugated
anti-Nerve Growth Factor Receptor (NGFR) (AA 281-421) antibodyNGFR 适用: 人 WB, IHC 宿主: 兔 Monoclonal NGFR-2550R unconjugated Recombinant Antibody
-
-
应用备注
-
WB: 1:150-1:2500
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 10 μL, 50 μL, 100 μL or 250 μL double distilled water (DDW), depending on the sample size.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- NGFR (Nerve Growth Factor Receptor (NGFR))
-
别名
- NGFR
-
背景
-
Synonyms: p75NTR, NGFR p75, TNFR superfamily member 16, TNFRSF16, CD271
Description: p75NTR known as a cell surface receptor for NGF, BDNF, NT-3 and NT-4, is also a receptor for b-amyloid, and for the myelin axon repellant protein MAG.1,2,4,6 Binding of neurotrophins induces receptor dimerization followed by phosphorylation of receptor kinase residues and recruitment of intracellular proteins involved in signal transduction. p75NTR functions alone, or in functional complexes with the neurotrophin receptors trkA, trkB and trkC. p75NTR signals via interaction with different transducers such as TRAF6, IRAK, and RIP-2, activating NF-κB, JNK and p38, and inactivating rhoA.1,3,6 Receptor degradation is mediated by a metalloproteinase-dependent shedding of the extracellular domain. p75NTR binds all neurotrophins with similar nM affinity, but binds pro-neurotrophins with greater affinity, and is more potently activated by pro-neurotrophins.5Overexpression of the intracellular domain in developing neurons induces apoptosis. NGF-dependent association of NRIF with p75NTR contributes to pro-apoptotic signaling.7,8 Beta-amyloid peptide binds p75NTR and stimulates pro apoptotic signaling by p75NTR, suggesting that the receptor may be relevant for Alzheimer's disease.9
-
基因ID
- 24596
-
NCBI登录号
- NM_002507
-
UniProt
- Q08201
-
途径
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
抗原
-
