HRH1 抗体 (AA 396-409)
Quick Overview for HRH1 抗体 (AA 396-409) (ABIN7043268)
抗原
See all HRH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 396-409
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原理
- A Rabbit Polyclonal Antibody to Histamine H1 Receptor
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特异性
- 3rd intracellular loop
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human,dog - 13,14 amino acid residues identical
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产品特性
- Anti-Histamine H1 Receptor (HRH1) Antibody (ABIN7043268, ABIN7044505 and ABIN7044506) is a highly specific antibody directed against an epitope of rat H1R. The antibody can be used in western blot, immunocytochemistry, indirect flow cytometry, and immunohistochemstry applications. It has been designed to recognize H1R from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)HSRQYVSGLHLNRE, corresponding to amino acids 396-409 of rat HRH1
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亚型
- IgG
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anti-Histamine Receptor H1 (HRH1) (AA 211-416) antibody
HRH1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H1 (HRH1) (Cytoplasmic Domain) antibodyHRH1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H1 (HRH1) (C-Term) antibodyVerified HRH1 适用: 人, 大鼠 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Histamine Receptor H1 (HRH1) (AA 176-191), (Extracellular) antibodyHRH1 适用: 小鼠 WB, IHC, IF, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H1 (HRH1) (Extracellular Domain) antibodyHRH1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H1 (HRH1) antibodyMicroarray verified HRH1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB551360 unconjugated
anti-Histamine Receptor H1 (HRH1) (AA 312-414) antibodyHRH1 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-Histamine Receptor H1 (HRH1) (Internal Region) antibodyHRH1 适用: 人 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H1 (HRH1) (Internal Region) antibodyVerified HRH1 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Cited Application: IHC|IFC
Negative Control: (ABIN7235750)
Blocking Peptide: (ABIN7235750)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- HRH1 (Histamine Receptor H1 (HRH1))
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别名
- HRH1
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背景
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H1R, HH1R,Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1-H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization.1H1 receptors are expressed in many cell types including endothelial and smooth muscle cells where they mediate vasodilatation and increased vascular permeability effects. H1R is widely distributed through the brain where it mediates sleep-wake cycles and regulates cognitive functions. The receptor is expressed in several cell populations involved in the immune response, including T-cells and B-cells, monocytes and eosinophiles.2,3H1 anti-histamine compounds have been available for almost thirty years and are among the most commonly used medication for conditions such as allergic inflammation. In addition, H1 anti-histamines are also prescribed for the treatment of insomnia and analgesia.2,3
Alternative names: Histamine H1 Receptor (HRH1), H1R, HH1R -
基因ID
- 24448
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NCBI登录号
- NM_032369
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UniProt
- P31390
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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