GLRA1 抗体 (2nd Cytoplasmic Loop)
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Quick Overview for GLRA1 抗体 (2nd Cytoplasmic Loop) (ABIN7043257)
抗原
See all GLRA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Cytoplasmic Loop, AA 350-362
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原理
- A Rabbit Polyclonal Antibody to Glycine Receptor α1
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 12,13 amino acid residues identical
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产品特性
- Anti-Glycine Receptor alpha1 Antibody is directed against an epitope of the rat glycine receptor α1. Anti-Glycine Receptor α1 Antibody (ABIN7043257, ABIN7044394 and ABIN7044395) can be used in western blot and immunohistochemical staining. It has been designed to recognize GlyRα1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RHHKSPMLNLFQD, corresponding to amino acid residues 350-362 of rat GlyRalpha1
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亚型
- IgG
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anti-Glycine Receptor, alpha 1 (GLRA1) (AA 121-220) antibody
GLRA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E6 unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 23-113) antibodyGLRA1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 29-154) antibodyGLRA1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7F8E2 unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) antibodyGLRA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 121-220) antibodyGLRA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D9 unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (Internal Region) antibodyVerified GLRA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (Internal Region) antibodyGLRA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) antibodyGLRA1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (AA 1-449) antibodyGLRA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glycine Receptor, alpha 1 (GLRA1) (Middle Region) antibodyGLRA1 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235712)
Blocking Peptide: (ABIN7235712)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GLRA1 (Glycine Receptor, alpha 1 (GLRA1))
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别名
- GLRA1
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背景
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Synonyms: Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, GLRA1, Glyr
Description: Glycine receptors (GlyRs) mediate ionotropic inhibitory neurotransmission in the CNS where they play an essential role in inhibition of motor neurons in the spinal cord and brainstem1. The glycine receptor is composed of three ligand-binding subunits of 48 kDa (α) and two homologous polypeptides of 58 kDa (β) that span the postsynaptic membrane in a pentameric arrangement to form a Cl--selective channel2. So far, at least three different α-subunit variants of the GlyR have been identified: α1, α2 and α33. Homo-oligomeric α2 receptors have a low strychnine-binding affinity and are considered to represent a neonatal form of GlyR, which is replaced during development by receptors containing the α1 subunit. Adult GlyRs are predominantly composed of α1 and β subunits, the α3 subunit being expressed at low levels in only a few brain regions4.GlyRα1 subunits are widely expressed and contribute to many processes in the CNS, including inflammatory pain perception, modulation of auditory and visual pathways, and neurotransmission in the cerebellar cortex5.Mutations in glycine receptor α1 subunits cause human hereditary hyperekplexia, a disorder characterized by an exaggerated startle response, which is a consequence of the role of GlyRs in motor reflex circuits of the spinal cord6.
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基因ID
- 25674
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NCBI登录号
- NM_000171
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UniProt
- P07727
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途径
- Synaptic Membrane
抗原
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