GLP1R 抗体 (Extracellular)
Quick Overview for GLP1R 抗体 (Extracellular) (ABIN7043219)
抗原
See all GLP1R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 288-301, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Glucagon-like Peptide 1 Receptor
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特异性
- 2nd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse,human - 13,14 amino acid residues identical
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产品特性
- Anti-GLP1R (extracellular) Antibody (ABIN7043219, ABIN7044406 and ABIN7044407) is a highly specific antibody directed against an epitope of the rat glucagon-like peptide 1 receptor. The antibody can be used in western blot, immunohistochemistry, immunocytochemistry, and live cell imaging applications. It has been designed to recognize GLP1R from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KYLYEDEG(S)WTRNS, corresponding to amino acid residues 288-301 of rat GLP1R
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亚型
- IgG
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anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (AA 101-200) antibody
GLP1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IP, ICC, FACS, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (AA 25-145) antibodyGLP1R 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (Internal Region) antibodyVerified GLP1R 适用: 人, 大鼠, Pig WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (AA 24-145) antibodyGLP1R 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (AA 22-116) antibodyGLP1R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (Cytoplasmic Domain) antibodyGLP1R 适用: 人, 小鼠, 兔, 犬, 猴, Pig, Bat, Hamster, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (N-Term) antibodyGLP1R 适用: 人, 小鼠 IHC, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (Center) antibodyGLP1R 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (AA 22-145) antibodyGLP1R 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glucagon-Like Peptide 1 Receptor (GLP1R) (AA 24-139) antibodyGLP1R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100-1:200
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: ICC
Negative Control: (ABIN7235607)
Blocking Peptide: (ABIN7235607)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GLP1R (Glucagon-Like Peptide 1 Receptor (GLP1R))
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别名
- GLP1R
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背景
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Glucagon-like peptide 1 receptor, GLP-1 receptor,Glucagon-like peptide 1 (GLP-1) is a hormone secreted by the intestine following a meal1. This hormone is known to enhance the secretion of insulin, important glucose blood level regulation2,3. In pancreatic β-cells, other than stimulating insulin secretion, GLP-1 action is also important for β-cell mass expansion2.GLP-1 exerts its biological functions through Glucagon-like peptide 1 receptor (GLP-1 receptor), a member of the G-protein coupled receptor superfamily. Like all members, this receptor spans the membrane seven times. GLP-1 receptor couples with Gs, thereby stimulating adenylate cyclase, consequently leading to an increase in cAMP2.The receptor is expressed in various tissues, namely the pancreas, adipose tissue, muscle, heart, gastrointestinal tract and liver. GLP-1 receptor is also found in the central nervous system where it provides a neuroprotective effect4.The glucagon-like peptide 1 system may serve as a therapeutic treatment in diabetes mellitus, in order to maintain β-cell mass expansion2. In addition, the receptor may serve as a therapy target in various neurodegenerative diseases like Alzheimer's and Parkinson's disease4.
Alternative names: GLP1R, Glucagon-like peptide 1 receptor, GLP-1 receptor -
基因ID
- 25051
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NCBI登录号
- NM_002062
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UniProt
- P32301
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途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Transport, cAMP Metabolic Process, Feeding Behaviour
抗原
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