FZD2 抗体 (Extracellular, N-Term)
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Quick Overview for FZD2 抗体 (Extracellular, N-Term) (ABIN7043141)
抗原
See all FZD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 192-205, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Frizzled-2
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交叉反应
- 人, 大鼠
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预测反应
- Human - identical, mouse - 13,14 amino acid residues identical
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产品特性
- Anti-Frizzled-2 (FZD2) (extracellular) Antibody is directed against an epitope of rat Frizzled-2. Anti-Frizzled-2 (FZD2) (extracellular) Antibody (ABIN7043141, ABIN7044285 and ABIN7044286) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize FZD2 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)GAPPRYATLEHPFH, corresponding to amino acid residues 192-205 of rat Frizzled-2
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亚型
- IgG
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anti-Frizzled Family Receptor 2 (FZD2) (Internal Region) antibody
Verified FZD2 适用: 人 WB, ELISA, IF, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (Internal Region) antibodyFZD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (AA 192-245) antibodyFZD2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C8 unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (N-Term) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, Hamster, Pig, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (Extracellular Domain) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, Hamster, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (N-Term) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) antibodyFZD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (N-Term) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (AA 201-250) antibodyFZD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235341)
Blocking Peptide: (ABIN7235341)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- FZD2 (Frizzled Family Receptor 2 (FZD2))
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别名
- FZD2
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背景
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Synonyms: Frizzled class receptor 2, Fz-2
Description: Frizzled receptors (FZD) belong to the superfamily of G-protein coupled receptors (GPCR). They are classified to the frizzled subfamily for which 11 members have been identified to date, FZD1-10 and Smoothened1. They were first identified in Drosophila melanogaster.Like all GPCRs, Frizzled receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. However, these receptors lack many features of the conventional class A, B or C GPCRs2.Activation of these receptors by WNT, leads to numerous complex signaling pathways which are generally termed β-catenin-dependent and β-catenin-independent. It is noteworthy to mention that the β-catenin-dependent pathway involves the interaction of FZD with LRP6 or LRP5 co-receptors3.Frizzled receptors are ubiquitously expressed and play a crucial role in embryo development. They are also significantly involved in proliferation and differentiation. Indeed, dysregulation of FZD leads to various forms of cancer1. Scientific evidence also shows their involvement in axonal remodeling and neurotransmitter release1.They have been associated to Alzheimer's and Parkinson's diseases, depression, anxiety, hypoxia and ischemia. It is thus not surprising that they have become pharmacological targets in a number of diseases and disorders.
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基因ID
- 64512
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NCBI登录号
- NM_001466
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UniProt
- Q08464
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途径
- WNT signaling
抗原
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