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- 抗原 See all FZD2 抗体
- FZD2 (Frizzled Family Receptor 2 (FZD2))
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抗原表位
- AA 192-205, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FZD2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Frizzled-2
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 大鼠
- 预测反应
- Human - identical, mouse - 13,14 amino acid residues identical
- 产品特性
- Anti-Frizzled-2 (FZD2) (extracellular) Antibody is directed against an epitope of rat Frizzled-2. Anti-Frizzled-2 (FZD2) (extracellular) Antibody (ABIN7043141, ABIN7044285 and ABIN7044286)) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize FZD2 from rat, mouse and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)GAPPRYATLEHPFH, corresponding to amino acid residues 192-205 of rat Frizzled-2
- 亚型
- IgG
- Top Product
- Discover our top product FZD2 Primary Antibody
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anti-Frizzled Family Receptor 2 (FZD2) (Internal Region) antibody
Verified FZD2 适用: 人 WB, ELISA, IF, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (Extracellular Domain) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, Hamster, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (N-Term) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, Hamster, Pig, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (AA 192-245) antibodyFZD2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C8 unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (Internal Region) antibodyFZD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (N-Term) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) antibodyFZD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (N-Term) antibodyFZD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 2 (FZD2) (AA 201-250) antibodyFZD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-FR022
Blocking Peptide: BLP-FR022
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- FZD2 (Frizzled Family Receptor 2 (FZD2))
- 别名
- FZD2 (FZD2 产品)
- 背景
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Frizzled class receptor 2, Fz-2,Frizzled receptors (FZD) belong to the superfamily of G-protein coupled receptors (GPCR). They are classified to the frizzled subfamily for which 11 members have been identified to date, FZD1-10 and Smoothened1. They were first identified in Drosophila melanogaster.Like all GPCRs, Frizzled receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. However, these receptors lack many features of the conventional class A, B or C GPCRs2.Activation of these receptors by WNT, leads to numerous complex signaling pathways which are generally termed β-catenin-dependent and β-catenin-independent. It is noteworthy to mention that the β-catenin-dependent pathway involves the interaction of FZD with LRP6 or LRP5 co-receptors3.Frizzled receptors are ubiquitously expressed and play a crucial role in embryo development. They are also significantly involved in proliferation and differentiation. Indeed, dysregulation of FZD leads to various forms of cancer1. Scientific evidence also shows their involvement in axonal remodeling and neurotransmitter release1.They have been associated to Alzheimer's and Parkinson's diseases, depression, anxiety, hypoxia and ischemia. It is thus not surprising that they have become pharmacological targets in a number of diseases and disorders.
Alternative names: Frizzled-2 (FZD2), Frizzled class receptor 2, Fz-2 - 基因ID
- 64512
- NCBI登录号
- NM_001466
- UniProt
- Q08464
- 途径
- WNT signaling
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