EPH Receptor A4 抗体 (Extracellular, N-Term)
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Quick Overview for EPH Receptor A4 抗体 (Extracellular, N-Term) (ABIN7043124)
抗原
See all EPH Receptor A4 (EPHA4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 485-499, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to EphA4 (extracellular).
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - identical
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产品特性
- A rabbit polyclonal antibody to EphA4 (extracellular).
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ERSYRIVRTAARNTD, corresponding to amino acid residues 485 - 499 of human EPHA4
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亚型
- IgG
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anti-EPH Receptor A4 (EPHA4) (AA 40-70), (N-Term) antibody
EPHA4 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB1587 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 621-882) antibodyEPHA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 887-986) antibodyEPHA4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H7 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 345-545) antibodyEPHA4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) antibodyEPHA4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 875-904), (C-Term) antibodyEPHA4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB1590 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 531-630) antibodyEPHA4 适用: 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 383-417) antibodyEPHA4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB50832 unconjugated
anti-EPH Receptor A4 (EPHA4) (Internal Region) antibodyEPHA4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 887-986) antibodyEPHA4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235286)
Blocking Peptide: (ABIN7235286)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- EPH Receptor A4 (EPHA4)
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别名
- EPHA4
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背景
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Synonyms: Ephrin Type-A Receptor 4, EPH-Like Kinase 8, EPHA4
Description: EphA4 is a member of the Eph receptor tyrosine kinase family.Eph receptors are subdivided into two subclasses, termed EphA and EphB, based on sequence similarity and their preference for binding a particular subclass of ephrins. The domain organization of Eph receptors contains a globular ligand binding domain (LBD), a cysteine-rich region, and two fibronectin type III domains (FN1 and FN2). It also contains a transmembrane (TM) helix, and an intracellular part consisting of a juxtamembrane (JM) region and a tyrosine kinase domain. Eph kinase activity is auto-inhibited through interaction with its own JM region, this auto inhibition is released by phosphorylation1.Interactions of Eph receptors with their ligands, ephrins, at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration2.EphA4 is activated by all members of the ephrin-A ligand family and most members of the ephrin-B family1. Upon ligand binding it activates pathways that regulate the formation of the axon tract and cortical network as well as radial migration of cortical neurons in the cortex3.EphA4 is expressed in the neural ectoderm at embryonic day 8 and then in various cell types throughout the cortex during subsequent stages of neurodevelopment4, its major effect on cell-cell interfaces makes this receptor highly important for the study of cellular regeneration and various types of disease.
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基因ID
- 2043
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NCBI登录号
- NM_001304536
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途径
- RTK signaling
抗原
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