EPH Receptor A2 抗体 (Extracellular, N-Term)
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Quick Overview for EPH Receptor A2 抗体 (Extracellular, N-Term) (ABIN7043122)
抗原
See all EPH Receptor A2 (EPHA2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 333-347, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to EphA2 Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - 14,15 amino acid residues identical, mouse - 13
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产品特性
- Anti-EphA2 (extracellular) Antibody (ABIN7043122, ABIN7044249 and ABIN7044250) is a highly specific antibody directed against an epitope of human EPHA2. The antibody can be used in western blot and live cell flow cytometry applications. It has been designed to recognize EphA2 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HYLTAVGMGAKVELR, corresponding to amino acid residues 333 - 347 of human EphA2
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亚型
- IgG
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anti-EPH Receptor A2 (EPHA2) (AA 30-60), (N-Term) antibody
EPHA2 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB01579 unconjugated
anti-EPH Receptor A2 (EPHA2) (AA 901-976) antibodyEPHA2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2 (EPHA2) (AA 204-326) antibodyEPHA2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E3 unconjugated
anti-EPH Receptor A2 (EPHA2) antibodyEPHA2 适用: 人 FACS, IF, cELISA 宿主: 小鼠 Monoclonal Kalpha-5H5 unconjugated
anti-EPH Receptor A2 (EPHA2) (AA 30-60) antibodyEPHA2 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2 (EPHA2) (AA 559-976) antibodyEPHA2 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3D7 unconjugated
anti-EPH Receptor A2 (EPHA2) (Tyr588), (Tyr596) antibodyEPHA2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2 (EPHA2) (AA 847-976) antibodyEPHA2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2 (EPHA2) antibodyEPHA2 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1B3C7 unconjugated
anti-EPH Receptor A2 (EPHA2) (AA 851-970) antibodyEPHA2 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235278)
Blocking Peptide: (ABIN7235278)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- EPH Receptor A2 (EPHA2)
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别名
- EPHA2
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背景
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Synonyms: Ephrin type A receptor 2, EPH Receptor A2, Epithelial Cell Kinase, Tyrosine-Protein Kinase Receptor ECK, ECK, EPHA2
Description: Erythropoietin-producing hepatocellular receptor A2 (EphA2) is a tyrosine kinase that belongs to the Ephrin (Eph) family of receptors. Members bind to cell surface-associated Ephrin ligands on neighboring cells. This binding generates bidirectional signaling which is a major form of contact-dependent communication between cells1. Eph receptors are divided into two classes, EphA and EphB, depending on the homology of their extracellular domains. Each extracellular domain is composed of a ligand-binding domain, Sushi domain, epidermal growth factor (EGF)-like domain, and two fibronectin type-III repeats. Eph receptors also contain a transmembrane domain, juxtamembrane region, tyrosine kinase domain, sterile alpha motif (SAM) and postsynaptic density (PSD)-95 protein, Discs large, and Zona occludens tight junction protein (PDZ) domain-binding motif.The interaction between Ephrin and the Eph receptor results in both "forward signaling" and "reverse signaling," which are mediated by Eph receptor and Ephrin, respectively2. Forward signaling induces Eph receptor oligomer clustering, cross-phosphorylation of tyrosine residues on the juxtamembrane domain and activation loop and, consequently, activation of the kinase activity.Eph receptor-ligand interactions mainly regulate cell proliferation and migration during development as well as tissue homeostasis, axon guidance, synapse plasticity, tissue remodeling, bone morphogenesis, and angiogenesis2.EphA2 is expressed in normal epidermal cells and in various solid tumors, such as breast, ovary, prostate, pancreas, glioblastoma, neck, renal, lung, melanoma, bladder and other types of cancer2.EphA2 expression in tumors is associated with a more aggressive cancer phenotype and correlates with tumor metastasis and poor patient outcome. In contrast, EphA2 also reduces cancer cell motility and proliferation and hence has both pro- and anti-oncogenic roles, depending on the cellular context3.Due to its pivotal role in various diseases, EphA2 is an appealing drug target and research is performed in order to control its activity4.
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基因ID
- 1969
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NCBI登录号
- NM_004431
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UniProt
- P29317
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途径
- RTK signaling
抗原
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