Contactin 1 抗体 (Extracellular)
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- 抗原 See all Contactin 1 (CNTN1) 抗体
- Contactin 1 (CNTN1)
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抗原表位
- AA 947-961, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Contactin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to Contactin-1 (extracellular)
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse - identical, human - 14,15 amino acid residues identical
- 产品特性
- Anti-Contactin-1/CNTN1 (extracellular) Antibody (ABIN7043083, ABIN7044738 and ABIN7044739)) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used western blot and immunohistochemistry applications. It has been designed to recognize CNTN1 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RPDGQHDGKLFSTHK, corresponding to amino acid residues 947 - 961 of rat Contactin-1
- 亚型
- IgG
- Top Product
- Discover our top product CNTN1 Primary Antibody
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anti-Contactin 1 (CNTN1) (AA 250-350) antibody
CNTN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) antibodyCNTN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) antibodyCNTN1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (Internal Region) antibodyVerified CNTN1 适用: 人, 大鼠, 小鼠, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 585-870) antibodyVerified CNTN1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (N-Term) antibodyCNTN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 686-866) antibodyCNTN1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (N-Term) antibodyCNTN1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 81-130) antibodyCNTN1 适用: 人, 大鼠, 豚鼠, Pig, 马, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Contactin 1 (CNTN1) (AA 301-350) antibodyCNTN1 适用: 人, 大鼠, 小鼠, 豚鼠, Pig, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200-1:400
- 说明
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Cited Application: IHC
Negative Control: BLP-NR171
Blocking Peptide: BLP-NR171
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Contactin 1 (CNTN1)
- 别名
- CNTN1 (CNTN1 产品)
- 背景
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Neural cell surface protein F3, Glycoprotein GP135, CNTN1,Contactin-1 (CNTN1), also known as F3/Contactin a cell adhesion molecule, is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein involved in neuronal development, synaptic maintenance and organization of neuronal networks. CNTNs are a subpopulation of molecules belonging to the immunoglobulin (Ig) superfamily, which includes six members: CNTN1, TAG-1/CNTN2, BIG-1/CNTN3, BIG-2/CNTN4, NB-2/CNTN5 and NB-3/CNTN61,2.In mammals, contactin-1 is mostly localized in the peripheral and central neural system. It is highly expressed at the axonal level and mediates various functions in both glial and neuronal cells, it is involved in neuronal and glial development and differentiation, myelination, synaptogenesis and synaptic function1.Contactin-1 expression profile differs in various brain regions and, within each area, it changes depending upon the cell type. For example, in the cerebellar cortex contactin-1 is predominant in granule cells in earlier developmental stages, whereas its activation is delayed in Purkinje neurons. In the hippocampus, it is detected on pyramidal neurons of CA1-CA3 fields and in granule layers of Dentate Gyrus (DG) where its expression persists in postnatally developed neurons. Hippocampal contactin-1 is highly expressed in the developing hippocampus, it progressively increases during postnatal life, but it declines during aging, paralleling cognitive impairment. This suggests that contactin-1 might play a role in memory processes, in line with studies indicating its involvement in neurotransmitter release and some forms of plasticity1.The role of contactin-1 in neurotransmitter release has been linked with its capability to regulate synaptic vesicle exocytosis. Contactin-1 overexpression had been shown to induce an increase of cAMP-Responsive Element Binding (CREB) phosphorylation, enhanced hippocampal-dependent LTP and memory especially in 12-months-old mice, where neurogenesis is particularly evident. Also, contactin-1 overexpression counteracts apoptosis, and induces an increase of the antiapoptotic- and neuroplasticity-pathway BDNF/CREB/Bcl-21,3.Contactin-1 plays an important role in cancer progression. The expression of contactin-1 is upregulated in primary lesions, and its expression level correlates with tumor metastasis in cancer patients. Studies have demonstrated that contactin-1 also plays a key role in diseases not related to the nervous system, and its most notable function is its participation in cancer progression, in cancers such as esophageal squamous cell carcinoma (ESCC), GC, lung adenocarcinoma, oral squamous cell carcinoma (OSCC), hepatocellular carcinoma and prostate cancer2,3.
Alternative names: Contactin-1, CNTN1, Neural cell surface protein F3, Glycoprotein GP135, CNTN1 - 基因ID
- 117258
- NCBI登录号
- NM_001843
- UniProt
- Q63198
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