CALHM1 抗体 (Intracellular) (Atto 594)
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- 抗原 See all CALHM1 抗体
- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
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抗原表位
- AA 252-265, Intracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CALHM1 antibody is conjugated to Atto 594
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应用范围
- Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)
- 原理
- A Rabbit Polyclonal Antibody to Calcium Homeostasis Modulator 1 Conjugated to the Fluorescent Dye ATTO-594
- 特异性
- Intracellular, C-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse - identical
- 产品特性
- Anti-CALHM1 Antibody (ABIN7043013, ABIN7044044 and ABIN7044045) is a highly specific antibody directed against an epitope of the human calcium homeostasis modulator protein 1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CALHM1 from rat, mouse, and human samples. \nAnti-CALHM1-ATTO Fluor-594 Antibody (ABIN7043014) is directly labeled with an fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The fluorescent label belongs to the class of Rhodamine dyes and can be used with fluorescent equipment typically optimized to detect Texas Red and Alexa-594. Anti-CALHM1-ATTO Fluor-594 Antibody has been tested in immunohistochemistry applications and is especially suited for experiments requiring simultaneous labeling of different markers.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EAMNHDLELGHTHG, corresponding to amino acid residues 252-265 of human CALHM1
- 亚型
- IgG
- Top Product
- Discover our top product CALHM1 Primary Antibody
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anti-Calcium Homeostasis Modulator 1 (CALHM1) (N-Term) antibody
CALHM1 适用: 人, 大鼠, 小鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 202-346) antibodyCALHM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 202-346) antibodyCALHM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 295-344) antibodyCALHM1 适用: 人, 大鼠, 小鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Modulator 1 (CALHM1) (AA 252-265), (Intracellular) antibodyCALHM1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: N/A
- 说明
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Negative Control: (ABIN7235005)
Blocking Peptide: (ABIN7235005)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 50 μL double distilled water (DDW).
- 浓度
- 0.8 mg/mL
- 缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
- 别名
- CALHM1 (CALHM1 产品)
- 背景
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Calcium homeostasis modulator 1, FAM26C,A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimer's disease (AD). Indeed Neuronal Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau1.Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism2,3. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum (ER) although it can be detected at the plasma membrane. A functional channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions1.In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD2.
Alternative names: CALHM1, Calcium homeostasis modulator 1, FAM26C - 基因ID
- 255022
- NCBI登录号
- NM_001001412
- UniProt
- Q8IU99
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