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MERTK 抗体 (Extracellular, N-Term)

The 兔多克隆 anti-MERTK antibody (ABIN7042974) specifically detects MERTK in WB, IHC, FACS 和 IF. The antibody is reactive with 小鼠 samples.

Multiplex staining of MERTK and Aquaporin 4 in rat parietal cortex. (MERTK 抗体 (Extracellular, N-Term))

IHC

Expression of MERTK in mouse hippocampus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-MERTK (extracellular) Antibody (ABIN7042974, ABIN7045326 and ABIN7045327), (1:300), followed by goat anti-rabbit-AlexaFluor-488 (green). (MERTK 抗体 (Extracellular, N-Term))

IHC

Expression of MERTK in rat cerebellum - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-MERTK (extracellular) Antibody (ABIN7042974, ABIN7045326 and ABIN7045327), (1:300), followed by goat anti rabbit conjugated with Alexa 488 (green). (MERTK 抗体 (Extracellular, N-Term))

IHC

Cell surface detection of MERTK in live intact mouse BV-2 microglia cell line: (black line) Cells. (MERTK 抗体 (Extracellular, N-Term))

FACS

Western blot analysis human HepG2 hepatocellular carcinoma cell line lysate (lanes 1 and 4), mouse BV-2 microglia cell line lysate (lanes 2 and 5) and human MEG-01 megakaryoblastic leukemia cell line lysate (lanes 3 and 6): - 1-3. (MERTK 抗体 (Extracellular, N-Term))

6 images

产品编号 ABIN7042974

发货至: 中国

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Quick Overview for MERTK 抗体 (Extracellular, N-Term) (ABIN7042974)

抗原

See all MERTK 抗体

MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This MERTK antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Discover our top product MERTK Primary Antibody

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AA 402-416, Extracellular, N-Term

原理

A Rabbit Polyclonal Antibody to MERTK Receptor

交叉反应

人, 小鼠, 大鼠

预测反应

Rat - identical, human - 13,15 amino acid residues identical

产品特性

Anti-MERTK (extracellular) Antibody (ABIN7042974, ABIN7045326 and ABIN7045327) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry, and live cell flow cytometry. It has been designed to recognize MERTK from human, rat, and mouse samples.

纯化方法

Affinity purified on immobilized antigen.

免疫原

(C)KPPIKRQDGELVGYR, corresponding to amino acid residues 402 - 416 of mouse MERTK

亚型

IgG
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 587-858) antibody
MERTK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 501-600) antibody
MERTK 适用: 小鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-489) antibody
MERTK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibody
MERTK 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 55-148) antibody
MERTK 适用: 人 IHC 宿主: 小鼠 Monoclonal MERTK-3015 unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibody
MERTK 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB17701 unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) antibody
MERTK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D2 unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 840-999) antibody
MERTK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibody
KD Validated MERTK 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2070 unconjugated Recombinant Antibody

anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 946-980), (C-Term) antibody
MERTK 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50416 unconjugated

应用备注

WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7234888)
Blocking Peptide: (ABIN7234888)

限制

仅限研究用
状态

Lyophilized

溶解方式

25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

浓度

0.8 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

别名

MERTK

背景

Synonyms: Receptor tyrosine kinase MerTK, C-Mer Proto-Oncogene Tyrosine Kinase, Mer, Proto-Oncogene C-Mer
Description: Myeloid-epithelial-reproductive tyrosine kinase, MERTK, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and MERTK) family, expressed in numerous cancers1.The extracellular N-terminal domain contains two immunoglobulin-like and two fibronectin 3 domains, followed by a hydrophobic single pass transmembrane domain, and a cytoplasmic C-terminal tail containing a tyrosine kinase domain1,2.Auto-phosphorylation induced by ligand binding influences a range of downstream signaling pathways and cellular functions2. The physiological roles of MERTK include regulation of tissue homeostasis and repair, innate immune control, and platelet aggregation. However, aberrant expression of this protein promotes neoplasia, cell cycle progression, proliferation and tumor growth, resistance to apoptosis, and promotion of tumor metastases.MERTK is involved in the activation of several canonic oncogenic signaling pathways in various types of cancers including: leukemia, non-small cell lung cancer, glioblastoma, melanoma, prostate cancer, breast cancer, colon cancer and gastric cancer1,3,4.Due to its pivotal role in cancer development and metastasis, multiple therapeutic approaches are currently in development to inhibit MERTK, including ligand "traps" and small-molecule tyrosine kinase inhibitors4.

基因ID

17289

NCBI登录号

NM_006343

UniProt

Q60805

途径

RTK signaling