ADRB1 抗体 (2nd Extracellular Loop)
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Quick Overview for ADRB1 抗体 (2nd Extracellular Loop) (ABIN7886061)
抗原
See all ADRB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 200-214
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原理
- A Rabbit Polyclonal Antibody to β1-Adrenergic Receptor
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交叉反应
- 小鼠, 大鼠
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预测反应
- Rat,Mouse,human - 14,15 amino acid residues identical
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产品特性
- Anti-β1-Adrenergic Receptor (extracellular) Antibody (ABIN7042902, ABIN7043924 and ABIN7043925) is a highly specific antibody directed against an extracellular epitope the rat β1-adrenoceptor. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize β1AR from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RAESDEARR(S)YNDPK, corresponding to amino acid residues 200-214 of rat ADRB1
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亚型
- IgG
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anti-Adrenergic, beta-1-, Receptor (ADRB1) (Internal Region) antibody
Verified ADRB1 适用: 人 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (AA 181-250) antibodyADRB1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (Middle Region) antibodyADRB1 适用: 人, 大鼠, 小鼠, 犬, Pig, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (AA 401-477) antibodyADRB1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (AA 150-250) antibodyADRB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (Center) antibodyADRB1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (AA 181-250) antibody (FITC)ADRB1 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal FITC
anti-Adrenergic, beta-1-, Receptor (ADRB1) (AA 180-229) antibodyADRB1 适用: 人, 大鼠, 小鼠, 犬, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-1-, Receptor (ADRB1) (2nd Extracellular Loop), (AA 200-214) antibody (FITC)KO Validated ADRB1 适用: 大鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:400
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234672)
Blocking Peptide: (ABIN7234672)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))
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别名
- ADRB1
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背景
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Synonyms: Beta-1 adrenoceptor, Beta-1 adrenoreceptor, ADRB1, ADRB1R, B1AR
Description: β-Adrenergic receptors (βAR) belong to the superfamily of G-protein coupled receptors (GPCRs). βAR stimulation by the sympathetic nervous system or circulating catecholamines is involved in peripheral blood circulation, metabolic regulation, muscle contraction, and central neural activities. In the heart, acute βAR stimulation serves as the most powerful means to regulate cardiac output in response to a fight-or-flight situation.There are three βAR subtypes, β1AR, β2AR and β3AR, in cardiac myocytes1. The receptors consist of seven membrane-spanning domains, three intra- and three extracellular loops, an extracellular N-terminal domain, and an intracellular C-terminal tail2.β1AR is the predominant receptor subtype expressed in human cardiomyocytes. β1AR is also expressed in the kidney3. It has been implicated in adipogenesis and memory formation4.β1AR has been widely connected with heart disease. Both the downregulation and overstimulation of β1AR have been connected to myocyte apoptosis. In addition, chronic heart failure is characterized by abnormalities in β1AR signal transduction. It was demonstrated that heart failure is also inducible in animal models by overexpression of components of the β1AR signal transduction cascade. Transgenic mice overexpressing β1AR develop, with aging, heart failure similar to that observed in dilated cardiomyopathy in humans5.
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基因ID
- 64508
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NCBI登录号
- NM_000684
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UniProt
- P18090
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途径
- cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation
抗原
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